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Sensitivity to Amphotericin B of in vitro Established Cell Lines

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Abstract

IT has been demonstrated that the antifungal lipophylic polyene amphotericin B inhibits eukaryotic cell growth by binding to sterols and making ‘holes’ in cell membranes1. Used at subinhibitory concentrations, it enhances penetration of other antibiotics into the cells of higher organisms in vitro and in vivo, showing a synergistic effect with a number of unrelated drugs1,2. It has also been demonstrated that higher doses of amphotericin B inhibit macromolecular syntheses, probably by severely damaging the cell membrane3.

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References

  1. Kinsky, S. C., A. Rev. Pharmac., 10, 119 (1970).

    Article  CAS  Google Scholar 

  2. Hackett, A. J., Sylvester, S. S., Joss, V. R., and Calvin, M., Proc. natn. Acad. Sci. U.S.A., 69, 3653 (1972).

    Article  ADS  CAS  Google Scholar 

  3. Medoff, G., Kwan, C. N., Schlessinger, D., and Kobayashi, G. S., Antimicrob. Ag. Chemother., 3, 441 (1973).

    Article  CAS  Google Scholar 

  4. Medoff, G., Kobayashi, G. S., Schlessinger, D., and Valeriote, F. A., Science N.Y. (in the press).

  5. MacPherson, I., and Montagnier, L., Virology, 23, 292 (1964).

    Article  Google Scholar 

  6. Pollack, R. E., Green, H., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 60, 126 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Littlefield, J. W., Science, N.Y., 145, 709 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Labella, T., Amati, P., and Marin, G., J. cell. comp. Physiol., 81, 347 (1973).

    Article  CAS  Google Scholar 

  9. Migeon, B. R., Biochem. Genet., 1, 305 (1968).

    Article  CAS  Google Scholar 

  10. Todaro, G. J., and Green, H., J. Cell Biol., 17, 299 (1963).

    Article  CAS  Google Scholar 

  11. Basilico, C., Matsuya, Y., and Green, H., J. Virol., 3, 140 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Marin, G., and Pugliatti-Crippa, L., Expl. Cell Res., 70, 253 (1972).

    Article  CAS  Google Scholar 

  13. Todaro, G. J., and Green, H., Science, N.Y., 147, 513 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Littlefield, J. W., and Basilico, C., Nature, 211, 250 (1966).

    Article  ADS  CAS  Google Scholar 

  15. Marin, G., and Littlefield, J. W., J. Virol., 2, 69 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Westerveld, A., Meera Khan, P., Visser, R. P. L. S., and Bootsma, D., Nature, 234, 24 (1971).

    Google Scholar 

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Authors and Affiliations

  1. International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples

    P. AMATI & C. LAGO

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  1. P. AMATI
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  2. C. LAGO
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AMATI, P., LAGO, C. Sensitivity to Amphotericin B of in vitro Established Cell Lines. Nature 247, 466–469 (1974). https://doi.org/10.1038/247466a0

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