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Noradrenaline binding and the search for catecholamine receptors

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Abstract

The binding of 3H-noradrenaline to intact cells and microsomes seems not to measure catecholamine receptor interactions, but rather a membrane catechol-binding protein which may be related to the enzyme, catechol-O-methyl transferase. True receptors are probably scarce and detection will require catecholamine derivatives of much higher specific activity than are at present available.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    Pedro Cuatrecasas, Guy P. E. Tell, Vincenzo Sica, Indu Parikh & Kwen-Jen Chang

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  1. Pedro Cuatrecasas
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  2. Guy P. E. Tell
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  3. Vincenzo Sica
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  4. Indu Parikh
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  5. Kwen-Jen Chang
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Cuatrecasas, P., Tell, G., Sica, V. et al. Noradrenaline binding and the search for catecholamine receptors. Nature 247, 92–97 (1974). https://doi.org/10.1038/247092a0

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  • DOI: https://doi.org/10.1038/247092a0

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