Abstract
The frequency of opiate receptors varies dramatically throughout the human and monkey brain. The authors describe a relationship between the distribution of opiate receptors and of neurotransmitters.
Similar content being viewed by others
References
Goldstein, A., Lowney, L. I., and Pal, B. K., Proc. natn. Acad. Sci., U.S.A., 68, 1742 (1971).
Pert, C. B., and Snyder, S. H., Science, N.Y., 179, 1011 (1973).
Pert, C. B., and Snyder, S. H., Proc. natn. Acad. Sci., U.S.A., 70, 2243 (1973).
Terenius, L., Acta Pharmac. Toxic., 32, 317 (1973).
Simon, E. J., Hiller, J. M., and Edelman, I., Proc. natn. Acad. Sci., U.S.A., 70, 1947 (1973).
Pasternak, G., and Snyder, S. H., Molec. Pharmac. (in the press).
Pert, C. B., and Snyder, S. H., Science, N.Y. (in the press).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).
Kuhar, M. J., Roth, R. H., and Aghajanian, G. K., J. Pharmac. exp. Ther., 181, 36 (1972).
Kuhar, M. J., Aghajanian, G. K., and Roth, R. H., Brain Res., 44, 165 (1972).
Kuhar, M. J., Sethy, V. H., Roth, R. H., and Aghajanian, G. K., J. Neurochem., 20, 581 (1973).
Korf, J., Aghajanian, G. K., and Roth, R. H., Eur. J. Pharmac., 21, 305 (1973).
Zigmond, M. J., Chalmers, J. P., Simpson, J. R., and Wurtman, R. J., J. Pharm. exp. Ther., 179, 20 (1971).
Uretsky, N. J., and Iversen, L. L., J. Neurochem., 17, 269 (1970).
Fahn, S., and Côté, L. J., J. Neurochem., 15, 209 (1968).
Côté, L. J., and Fahn, S., Prog. Neurogenet., 1, 311 (1967).
Côté, L. J., and Fahn, S., in International Encyclopedia of Pharmacology and Therapeutics (edit. by Hornykiewicz, O.) (in the press).
Peters, D. A. V., McGeer, P. L., and McGeer, E. G., J. Neurochem., 15, 1431 (1968).
Yaksh, T., and Pert, A., Proc. Soc. Neurosci. (in the press).
Herz, A., and Teschemacher, H. J., Adv. Drug Res., 6, 79 (1971).
Tsou, K., and Jang, C. S., Scientia Sinica, 13, 99 (1964).
Wei, E., Loh, H. H., and Way, E. L., J. Pharmacol. exp. Ther., 185, 108 (1973).
Nauta, W. J. H., in Electrical Studies on the Unanesthetized Brain (edit. by Ramey, E. R., and O'Doherty, D. S.), 1 (Hoeber, New York, 1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KUHAR, M., PERT, C. & SNYDER, S. Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain. Nature 245, 447–450 (1973). https://doi.org/10.1038/245447a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/245447a0
- Springer Nature Limited
This article is cited by
-
Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches
Molecular Psychiatry (2019)
-
Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging
Journal of Molecular Histology (2017)
-
Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study
Scientific Reports (2016)
-
Pharmacological traits of delta opioid receptors: pitfalls or opportunities?
Psychopharmacology (2013)
-
Heroin Spongiform Leukoencephalopathy (HSLE)
Clinical Neuroradiology (2012)