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Development of Glucose Oxidation in Isolated Nerve Endings

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Abstract

A HIGH proportion of oxidative metabolism in the cerebral cortex is thought to occur in dendritic areas which are rich in synapses1,2. With the development of methods to prepare isolated nerve endings (synaptosomes) from brain3, it has become possible to investigate the characteristics of oxidative metabolism at the synapse without significant glial contamination4,5. Glucose is taken up into synaptosomes by a high-affinity carrier-mediated transport process6 and subsequently oxidized to support synthesis of ATP and phosphocreatine4,5. Mitochondria probably do not metabolize glucose directly4,5 and glucose transport and metabolism are largely abolished if synaptosomes are ruptured by hyposmotic shock4,6.

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Authors and Affiliations

  1. Departments of Neurology and Pediatrics, University of California School of Medicine, San Francisco, California, 94122

    I. DIAMOND

  2. Department of Neurology, University of California School of Medicine, San Francisco, California, 94122

    R. A. FISHMAN

Authors
  1. I. DIAMOND
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  2. R. A. FISHMAN
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DIAMOND, I., FISHMAN, R. Development of Glucose Oxidation in Isolated Nerve Endings. Nature 243, 519–520 (1973). https://doi.org/10.1038/243519a0

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  • DOI: https://doi.org/10.1038/243519a0

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