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T Cell-dependent Mediator in the Immune Response

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Abstract

SUPERNATANTS of allogeneic lymphocyte cultures enable bone-marrow derived (lymphocytes) to respond to sheep red blood cells (SRBC) in vitro1–3. It was suggested that a non-specific T cell-dependent mediator may be involved in the normal immune response to this antigen. Indeed, T cells educated to one erythrocyte antigen can, in the presence of that antigen, greatly facilitate the response of B cells to other non-cross reacting erythrocytes4,5. T cells educated to protein antigens can also generate such a non-specific event in the interaction of T and B cells in vitro6. The following experiments were designed to establish whether in this syngeneic system the phenomenon was dependent on the production of soluble mediators after activation of T cells by protein antigen.

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Authors and Affiliations

  1. Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge

    H. WALDMANN & A. MUNRO

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  1. H. WALDMANN
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  2. A. MUNRO
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WALDMANN, H., MUNRO, A. T Cell-dependent Mediator in the Immune Response. Nature 243, 356–357 (1973). https://doi.org/10.1038/243356a0

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