Abstract
THE penicillin focus has been widely used as an experimental model in the study of epilepsy on which most of our knowledge about the electrophysiological cellular mechanisms of this disease is based. According to current views epileptic phenomena are related to an impairment of excitation-inhibition relationships in the brain. Transition from the inter-ictal stage to seizures results from an abolishment or weakening of inhibitory effects1. Gamma-aminobutyric acid (GABA) was strongly implied in cortical inhibitory mechanisms and is thought to act as an inhibitory neurotransmitter2,3; glutamate has excitatory properties and is a possible excitatory neurotransmitter2. Estimations of GABA and glutamate contents in the brain have been made in animals in which convulsions were induced by convulsive hydrazides, pentamethylenetetrazole, picrotoxin, methionine sulphoximine and high oxygen pressure4–10. Berl and Waelsch11 compared levels of GABA and glutamate in a cortical spiking focus, produced by freezing, with levels in the surrounding tissue. We demonstrate here levels of GABA and glutamate in penicillin produced cortical foci, in the inter-ictal and ictal stages respectively, as compared with levels in control animals.
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References
Ayala, G. F., Matsumoto, H., and Gumnit, R. J., J. Neurophysiol., 33, 73 (1970).
Krnjevic, K., Nature, 228, 119 (1970).
Bloom, F. E., (edit.), Neurosci. Res. Bull., 10, 2 (1972).
Tower, D. B., Neurochemistry of Epilepsy (Thomas, Springfield, 1960).
Killam, K. F., J. Pharmac. Exp. Ther., 119, 263 (1957).
Roa, P. D., Tews, J. K., and Stone, W. E., Biochem. Pharmacol., 13, 477 (1964).
Nahorsky, S. R., Roberts, D. J., and Stewart, G. G., J. Neurochem., 17, 621 (1970).
Saito, Sh., and Tokunaga, Y., J. Pharmac. Exp. Ther., 157, 546 (1967).
Tews, J. K., and Stone, W. E., Prog. Brain Res., 16, 135 (1965).
Wood, J. D., and Watson, W. J., Can. J. Biochem. Physiol., 41, 1907 (1963).
Berl, S., and Waelsch, H., J. Neurochem., 3, 161 (1958).
Strasberg, P., and Elliott, K. A. C., Can. J. Biochem., 45, 1795 (1967).
Popov, N., Pohle, W., Rösler, V., and Matthies, H., Acta Biol. Med. Ger., 18, 695 (1967).
McIlwain, H., and Bachelard, H. S., Biochemistry of the Central Nervous System (Churchill Livingstone, Edinburgh, 1971).
Leonard, B. E., and Palfreyman, M. G., Biochem. Pharmac., 21, 1206 (1972).
Baxter, C. F., and Roberts, E., Proc. Soc. Exp. Biol. Med., 104, 426 (1960).
Maynert, E. W., and Kaji, H. K., J. Pharmac. Exp. Ther., 137, 114 (1962).
Kuriyama, K., Roberts, E., and Rubinstein, M. K., Biochem. Pharmac., 15, 221 (1966).
Elliott, K. A. C., Jap. J. Brain Physiol., 84, 4 (1967).
Van Gelder, N. M., Sherwin, A. L., and Rasmussen, T., Brain Research, 40, 385 (1972).
Swanson, Ph. D., Arch. Neurol., 26, 169 (1972).
Richter, D., and Dawson, R. M. C., J. Biol. Chem., 176, 1199 (1948).
Stone, W. E., in Jasper, H. H., Ward, A. A., and Pope, A., (eds.), Basic Mechanisms of Epilepsies (Little, Brown, Boston, 1967).
Roberts, E., and Frankel, S., J. Biol. Chem., 190, 505 (1951).
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GOTTESFELD, Z., ELAZAR, Z. GABA and Glutamate in Different EEG Stages of the Penicillin Focus. Nature 240, 478–479 (1972). https://doi.org/10.1038/240478a0
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DOI: https://doi.org/10.1038/240478a0
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