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Rational Design of Degradable Insecticides

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Abstract

I HAVE used a sterically based hypothesis of the mode of action of aryl insecticides, including DDT1, to predict possible structures of new compounds, the synthesis2 of which has been directed at finding insecticides with low mammalian toxicity and which, because of their inherent chemical instability, would readily degrade. Insecticidal activity has been studied in susceptible and resistant housefly and investigations have been made of acute mammalian toxicity and chemical in vitro degradation.

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References

  1. Holan, G., Nature, 221, 1025 (1969).

    Article  ADS  CAS  Google Scholar 

  2. C.S.I.R.O., Australian Patent Applications Nos. 33896/68, 40743/68, 40745/68, PA 1945/70, PA 2367/70.

  3. Narahashi, T., and Haas, H. G., J. Gen. Physiol., 51, 177 (1968).

    Article  CAS  Google Scholar 

  4. Rogers, E. F., Brown, H. D., Rasmussen, I. M., and Heal, R. E., J. Amer. Chem. Soc., 75, 2991 (1953).

    Article  CAS  Google Scholar 

  5. Skerrett, E. J., and Woodcock, D., J. Chem. Soc., 2718 (1950).

  6. Hass, H. B., Neher, M. B., and Blickenstaff, R. T., Ind. Eng. Chem., 43, 2875 (1951).

    Article  CAS  Google Scholar 

  7. Jacob, T. A., Bachman, G. B., and Hass, H. B., J. Org. Chem., 16, 1572 (1951).

    Article  CAS  Google Scholar 

  8. Agosin, M., Michaeli, D., Miskus, R., Nagasawa, S., and Hoskins, W. M., J. Econ. Entomol., 54, 340 (1961).

    Article  Google Scholar 

  9. Stritmatter, P., in Biological Oxidations (edit. by Singer, T. P.), 171 (Interscience, New York, 1968).

    Google Scholar 

  10. Wilkinson, C. F., World Review of Pest Control, 7, 155 (1968).

    Google Scholar 

  11. Tsukamoto, M., Botyu Kagaku, 25, 156 (1960).

    Google Scholar 

  12. Margerum, J. D., Pitts, jun., J. N., Rutgers, J. G., and Searles, S., J. Amer. Chem. Soc., 81, 1549 (1959).

    Article  CAS  Google Scholar 

  13. Arnold, D. R., in Adv. in Photochem. (edit. by Noyes, jun., W. A., Hammond, G. S., and Pitts, jun., J. N.), 7, 340 (Interscience, New York, 1968).

    Google Scholar 

  14. Holan, G., Bull. Wld. Health Org. (in the press).

  15. Lipke, H., and Kearns, C. W., Advan. Pest Control Res., 3, 253 (1960).

    CAS  Google Scholar 

  16. Plapp, jun., J. N., in Biochemical Toxicology of Insecticides (edit. by O'Brien, R. D., and Yamamoto, I.), 179 (Academic Press, New York, 1970).

    Google Scholar 

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Authors and Affiliations

  1. Division of Applied Chemistry, CSIRO, P.O. Box 4331, Melbourne, Victoria, 3001

    G. HOLAN

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  1. G. HOLAN
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HOLAN, G. Rational Design of Degradable Insecticides. Nature 232, 644–647 (1971). https://doi.org/10.1038/232644b0

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  • DOI: https://doi.org/10.1038/232644b0

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