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Reductant-activation of Inorganic Pyrophosphatase : an ATP-conserving Mechanism in Anaerobic Bacteria

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Abstract

INORGANIC pyrophosphatases are key enzymes in the biosynthesis of proteins, nucleic acids and polysaccharides the polymerization of which takes place by reaction sequences in which a nucleoside triphosphate (NTP) reacts with a monomer (R) or monomer phosphate to give an “active” monomer (here simplified to NMPR) plus inorganic pyrophosphate (PPi): Polymerization takes place by transfer of the active monomer to the polymer chain and release of nucleotide Because the equilibrium of reaction (1) generally lies to the left, the formation of active monomer is “pulled” by inorganic pyrophosphatases

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Authors and Affiliations

  1. ARC Unit of Nitrogen Fixation, University of Sussex, Brighton, BN1 9QJ, Sussex

    D. WARE & J. R. POSTGATE

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  1. D. WARE
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  2. J. R. POSTGATE
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WARE, D., POSTGATE, J. Reductant-activation of Inorganic Pyrophosphatase : an ATP-conserving Mechanism in Anaerobic Bacteria. Nature 226, 1250–1251 (1970). https://doi.org/10.1038/2261250a0

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  • DOI: https://doi.org/10.1038/2261250a0

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