Abstract
CHROMOSOME analysis can be performed on fibroblasts cultured from amniotic fluid1–3. This is the basis of a technique for the intrauterine detection of chromosomal aberrations in the foetuses of women who are known to have a high risk of producing abnormal offspring. Valenti et al.1, for example, reported the intrauterine detection of trisomy 21 in amniotic fluid cell cultures and they subsequently performed a therapeutic abortion. The pathological findings on the foetus confirmed the diagnosis.
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References
Valenti, C., Schutta, E. J., and Kehaty, T., Lancet, ii, 220 (1968).
Steele, M. W., and Breg, jun., W. R., Lancet, i, 383 (1966).
Nadler, H. L., Pediatrics, 42, 912 (1968).
Lancet, ii, 89 (1969).
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LISGAR, F., GERTNER, M., CHERRY, S. et al. Prenatal Chromosome Analysis. Nature 225, 280–281 (1970). https://doi.org/10.1038/225280a0
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DOI: https://doi.org/10.1038/225280a0
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