Abstract
The transformation—as manifested by focus formation—of chick fibroblasts infected with Rous sarcoma virus is ten times more strongly suppressed by rifampicin than replication of the virus itself.
Similar content being viewed by others
References
Wehrli, W., Nüesch, J., Knüsel, F., and Staehelin, M., Biochem. Biophys. Acta, 157, 215 (1968).
Sippel, A., and Hartmann, G., Biochim. Biophys. Acta, 157, 218 (1968).
Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).
Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).
Ben-Ishai, Z., Heller, E., Goldblum, N., and Becker, Y., Nature, 224, 29 (1969).
Moss, B., Katz, E., and Rosenblum, E. N., Biochem. Biophys. Res. Commun., 36, 858 (1969).
Robinson, W. S., Pitkanen, A., and Rubin, H., Proc. US Nat. Acad. Sci., 54, 137 (1965).
Temin, H. M., and Rubin, H., Virology, 8, 209 (1959).
Temin, H. M., and Rubin, H., Virology, 6, 669 (1958).
Rubin, H., Virology, 4, 533 (1957).
Rubin, H., Proc. US Nat. Acad. Sci., 46, 1105 (1960).
Robinson, W. S., Robinson, H. L., and Duesberg, P. H., Proc. US Nat. Acad. Sci., 58, 825 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DIGGELMANN, H., WEISSMANN, C. Rifampicin inhibits Focus Formation in Chick Fibroblasts infected with Rous Sarcoma Virus. Nature 224, 1277–1279 (1969). https://doi.org/10.1038/2241277a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2241277a0
- Springer Nature Limited
This article is cited by
-
Induction of cytotoxic action by rifamycin in a system of normal allogeneic lymphocytes-target cells in vitro
Bulletin of Experimental Biology and Medicine (1974)
-
RNA polymerase activity in human brain tumors
Acta Neuropathologica (1974)
-
Effect of Dimethylbenzyldesmethylrifampicin (DMB) on Chemically Induced Mammary Tumours in Rats
Nature New Biology (1973)
-
Inhibitory effect of streptonigrin on a murine sarcoma virus-induced tumor cell line (MSC) and selection of drug-resistant clones
In Vitro (1973)
-
Reverse Transcriptase, RNA Tumour Virus Transformation and Derivatives of Rifamycin SV
Nature New Biology (1972)