Abstract
A genetic marker for the γA2 immunoglobulin has been delineated by precipitating and haemagglutination inhibition techniques with a human antiserum. The marker varies widely in incidence in different population groups. Although associated with all the major Gm gene complexes, a close linkage to the Gm system was found in family studies.
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Natvig, J. B., and Kunkel, H. G., Series Haematologica, 1, 66 (1968).
Natvig, J. B., Kunkel, H. G., Yount, W. J., and Nielsen, J. C., J. Exp. Med., 128, 763 (1968).
Kunkel, H. G., Natvig, J. B., and Joslin, F. G., Proc. US Nat. Acad. Sci., 62, 144 (1969).
Yount, W. J., Hong, R., Seligmann, M., and Kunkel, H. G., J. Clin. Invest. (in the press).
Grey, H. M., Abel, C. A., Yount, W. J., and Kunkel, H. G., J. Exp. Med., 128, 1223 (1968).
Gold, E. R., and Fudenberg, H. H., J. Immunol., 99, 859 (1967).
Herzenberg, L. A., Cold Spring Harbor Symp. Quant. Biol., 29, 455 (1964).
Potter, M., and Lieberman, R., in Advances in Immunology (edit. by Dixon, F. J., and Kunkel, H. G.), 7, 91 (Academic Press, New York, 1967).
Vyas, G. N., and Fudenberg, H. H., Clin. Res., 17, 469 (1969).
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KUNKEL, H., SMITH, W., JOSLIN, F. et al. Genetic Marker of the γA2 Subgroup of γA Immunoglobulins. Nature 223, 1247–1248 (1969). https://doi.org/10.1038/2231247a0
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DOI: https://doi.org/10.1038/2231247a0
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