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Self-protective Activity of Colostral IgA against Tryptic Digestion

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Abstract

ALTHOUGH the amount of IgA in serum is small compared with the amount of IgG, IgA is predominant in secretory fluids such as colostrum, saliva, nasal fluid and tears1–3. IgA from the colostrum and saliva4 has a higher sedimentation constant (11S) than serum IgA (7S), and 11S colostral IgA has additional antigenic determinants with specificities which are not present in serum IgA. In addition to the heavy (α) and light chains present in the molecule of serum IgA, colostral IgA has another protein component—the transport piece5.

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Authors and Affiliations

  1. Department of Biochemistry,

    BONG-SOP SHIM, YOON-SE KANG & WOO-JUNG KIM

  2. Department of Pediatrics, Catholic Medical College, Seoul, Korea

    SUNG-HOON CHO & DU-BONG LEE

Authors
  1. BONG-SOP SHIM
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  2. YOON-SE KANG
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  3. WOO-JUNG KIM
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  4. SUNG-HOON CHO
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  5. DU-BONG LEE
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SHIM, BS., KANG, YS., KIM, WJ. et al. Self-protective Activity of Colostral IgA against Tryptic Digestion. Nature 222, 787–788 (1969). https://doi.org/10.1038/222787a0

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  • DOI: https://doi.org/10.1038/222787a0

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