Abstract
The imidazole groups of the C-terminal histidines of the β-chains, together with the α-amino groups of the α-chains, are responsible for most of the Bohr effect. In oxyhaemoglobin these groups are free, while in deoxyhaemoglobin their pKs are raised, probably by linkage to carboxyl groups.
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PERUTZ, M., MUIRHEAD, H., MAZZARELLA, L. et al. Identification of Residues responsible for the Alkaline Bohr Effect in Haemoglobin. Nature 222, 1240–1243 (1969). https://doi.org/10.1038/2221240a0
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