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Effects of Antilymphocyte Serum on Induction of Tumours and Leukaemia by Murine Sarcoma Virus

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Abstract

THE suppression of immune reactions has helped to analyse their role in controlling neoplastic growths. The frequency of neoplasms which contain virus-specific transplantation antigens usually is strikingly increased in animals thymectomized during the neonatal period or given antilymphocyte serum (ALS). Experimental animals infected with SV 40 virus, adenovirus type 12, and polyoma virus—oncogenic viruses that do not induce tolerance—or with the murine sarcoma virus (MSV) show more tumours at an earlier age if they are thymectomized or treated with ALS (refs. 1–6). In at least one system using induction by polyoma virus of neoplasms in C57B1 mice, the major determinants of tumour induction and control have been shown to be the virus-specific transplantation antigen and the immune response of the tumour bearing host7.

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Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland

    LLOYD W. LAW & R. C. TING

  2. Clinical Research Centre, National Institute for Medical Research, London

    A. C. ALLISON

Authors
  1. LLOYD W. LAW
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  2. R. C. TING
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  3. A. C. ALLISON
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LAW, L., TING, R. & ALLISON, A. Effects of Antilymphocyte Serum on Induction of Tumours and Leukaemia by Murine Sarcoma Virus. Nature 220, 611–612 (1968). https://doi.org/10.1038/220611b0

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