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Relationship between the Action of Monoamine Oxidase Inhibitors on the Noradrenaline Uptake System and their Antidepressant Efficacy

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Abstract

MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1–3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4–7 and potentiating its effects in the brain.

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References

  1. Klerman, G. L., and Cole, J. O., Pharmacol. Rev., 17, 101 (1965).

    PubMed  CAS  Google Scholar 

  2. Hordern, A., Burt, C. G., and Holt, N. F., Depressive States (Charles C. Thomas, Springfield, Ill., 1965).

    Google Scholar 

  3. Davis, J. M., Arch. Gen. Psychiat., 13, 552 (1965).

    Article  CAS  Google Scholar 

  4. Axelrod, J., Rec. Prog. Horm. Res., 21, 597 (1965).

    PubMed  CAS  Google Scholar 

  5. Iversen, L. L., The Uptake and Storage of Noradrenaline in Sympathetic Nerves (University Press, Cambridge, 1967).

    Google Scholar 

  6. Bunney, W. E., and Davis, J. M., Arch. Gen. Psychiat., 13, 483 (1965).

    Article  CAS  Google Scholar 

  7. Schildkraut, J. J., and Kety, S. S., Science, 156, 21 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Iversen, L. L., Adv. Drug. Res., 2, 5 (1965).

    Google Scholar 

  9. McIlwain, H., and Rodnight, R., Practical Neurochemistry (Churchill, London, 1962).

    Google Scholar 

  10. Krebs, H. A., and Henseleit, K., Z. Physiol. Chem., 210, 33 (1932).

    Article  CAS  Google Scholar 

  11. Snyder, S. H., and Hendley, E. D., J. Pharmacol. Exp. Therap., 163, 386 (1968).

    CAS  Google Scholar 

  12. Biel, J. H., Horita, A., and Drukker, A. E., in Psychopharmacological Agents I (edit. by Gordon, M), 359 (Academic Press, New York, 1964).

    Google Scholar 

  13. Zirkle, C. L., and Kaiser, C., in Psychopharmacological Agents I (edit. by Gordon, M.), 445 (Academic Press, New York, 1964).

    Google Scholar 

  14. Bates, T. J. N., and Douglas, A. D. Mcl., J. Ment. Sci., 107, 358 (1961).

    Article  Google Scholar 

  15. Snyder, S. H., Amer. J. Orthopsychiat., 37, 864 (1967).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Departments of Pharmacology and Experimental Therapeutics and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland

    EDITH D. HENDLEY & SOLOMON H. SNYDER

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  1. EDITH D. HENDLEY
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  2. SOLOMON H. SNYDER
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HENDLEY, E., SNYDER, S. Relationship between the Action of Monoamine Oxidase Inhibitors on the Noradrenaline Uptake System and their Antidepressant Efficacy. Nature 220, 1330–1331 (1968). https://doi.org/10.1038/2201330a0

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