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Tremorgenic Toxin from Penicillium cyclopium grown on Food Materials

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Abstract

DRUGS and other compounds capable of causing sustained trembling are rare; in a survey of ten thousand compounds Everett et al. found less than ten with this property1. One of the best known is tremorine (1,4-dipyrrolidine-2-butyne) which is converted into a more active compound, oxotremorine2, by body tissues. Various synthetic amino alcohols also stimulate prolonged tremors, but their mechanism of action differs from that of tremorine and other more familiar compounds3.

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References

  1. Everett, G. M., Blockus, L. E., and Shepperd, I. M., Science, 124, 79 (1956).

    Article  ADS  CAS  Google Scholar 

  2. Hammer, W., Karlen, B., Rane, A., and Sjoquist, F., Life Sci., 7, 197 (1968).

    Article  CAS  Google Scholar 

  3. Ahmed, A., Marshall, P. B., and Shepherd, D. M., J. Pharm. Pharmacol., 10, 672 (1958).

    Article  CAS  Google Scholar 

  4. Wilson, B. J., and Wilson, C. H., Science, 144, 177 (1964).

    Article  ADS  CAS  Google Scholar 

  5. Wilson, B. J., Bact. Rev., 30, 478 (1966).

    CAS  PubMed  Google Scholar 

  6. Holzapfel, C. W., Tetrahedron, 24, 2101 (1968).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee

    BENJAMIN J. WILSON, CHRISTINA H. WILSON & A. WALLACE HAYES

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  1. BENJAMIN J. WILSON
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  2. CHRISTINA H. WILSON
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  3. A. WALLACE HAYES
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WILSON, B., WILSON, C. & HAYES, A. Tremorgenic Toxin from Penicillium cyclopium grown on Food Materials. Nature 220, 77–78 (1968). https://doi.org/10.1038/220077b0

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  • DOI: https://doi.org/10.1038/220077b0

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