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Daily Circadian Rhythm in Rats to D-Amphetamine Sulphate: Effect of Blinding and Continuous Illumination on the Rhythm

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Abstract

SEVERAL daily drug-susceptibility rhythms have been reported in rodents1–12. This report demonstrates the daily pattern in susceptibility to D-amphetamine sulphate as measured by percentage of mortality for normal rats housed in a light-dark (LD) environment, for rats maintained in continuous illumination (LL) and for blinded rats kept in continuous darkness (DD).

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References

  1. Carlsson, A., and Serin, F., Acta Pharmacol., 6, 187 (1950).

    Article  CAS  Google Scholar 

  2. Haus, E., and Halberg, F., J. Appl. Physiol., 14, 878 (1959).

    Article  CAS  PubMed  Google Scholar 

  3. Marte, E., and Halberg, F., Fed. Proc., 20, 305 (1961).

    Google Scholar 

  4. Davis, W. M., Experientia, 18, 235 (1962).

    Article  CAS  PubMed  Google Scholar 

  5. Davis, W. M., and Webber, O. L., Med. Exp., 9, 263 (1963).

    CAS  PubMed  Google Scholar 

  6. Haus, E., Ann. NY Acad. Sci., 117, 292 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Van Pilsum, J., Ann. NY Acad. Sci., 117, 337 (1964).

    Article  CAS  Google Scholar 

  8. Ertel, R. J., Halberg, F., and Unger, F., J. Pharmacol. Exp. Therap., 146, 395 (1964).

    CAS  Google Scholar 

  9. Matthews, J. H., Marte, E., and Halberg, F., Canad. Anesthesiol. Soc. J., 11, 280 (1964).

    Article  CAS  Google Scholar 

  10. Lutsch, E. F., and Morris, R. W., Science, 156, 100 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Scheving, L. E., and Vedral, D. F., Anat. Rec., 154, 417 (1966).

    Google Scholar 

  12. Pauly, J. E., and Scheving, L. E., Intern. J. Neuropharmacol., 3, 651 (1964).

    Article  CAS  Google Scholar 

  13. Scheving, L. E., and Pauly, J. E., Amer. J. Physiol., 210, 1112 (1966).

    CAS  PubMed  Google Scholar 

  14. Scheving, L. E., Vedral, D. F., and Pauly, J. E., Anat. Rec. (in the press).

  15. Scheving, L. E., and Pauly, J. E., J. Cell Biol., 32, 677 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Aschoff, J., Ann. Rev. Physiol., 25, 581 (1963).

    Article  CAS  Google Scholar 

  17. Reinberg, A., Perspect. Biol. Med., 11, 111 (1967).

    Article  CAS  PubMed  Google Scholar 

  18. Halberg, F., Cold Spring Harbor Symp. Quant. Biol., 25, 289 (1960).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, Louisiana State University, New Orleans, Louisiana

    LAWRENCE E. SCHEVING

  2. Department of Anatomy, University of Cincinnati, Cincinnati, Ohio

    DONALD F. VEDRAL

  3. Department of Anatomy, University of Arkansas, Little Rock, Arkansas

    JOHN E. PAULY

Authors
  1. LAWRENCE E. SCHEVING
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  2. DONALD F. VEDRAL
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  3. JOHN E. PAULY
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SCHEVING, L., VEDRAL, D. & PAULY, J. Daily Circadian Rhythm in Rats to D-Amphetamine Sulphate: Effect of Blinding and Continuous Illumination on the Rhythm. Nature 219, 621–622 (1968). https://doi.org/10.1038/219621a0

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  • DOI: https://doi.org/10.1038/219621a0

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