Summary
The mortality of mature, male B1 mice upon exposure to 35 per cent Fluothane in oxygen for 10 minutes may be as low as 5 per cent oi as high as 76 per cent, depending upon the oiganism’s circadian system phase, Predictably peiiodic changes in susceptibility can be found in test animals of several age groups, apart from differences in susceptibility as a function of age Further consideration of the organism’s time structure, as revealed by its rhythms, may lead to safer anaesthetic practices.
Résumé
Nous faisons une étude de la toxicité de ľhalothane, en nous servant de souris et de la méthode ďanalyse de périodicité indirecte Ce travail rapporte des résultats expérimentaux sur une cycle circadien (circa, dies, un rhythme dont la période est ďenviron 24 heures) dans la resistance ďun organisme vis-à-vis de ľhalothane En tenant compte du facteur temps et de facteurs de technique biologique expérimentale, la mortalité de souris B mâles—ayant respiré des vapeurs ďhalothane à 35 pour cent dans ľoxygène durant 7 à 10 minutes-aurait varié de 5 à 76 pour cent selon la phase du système circadien, i e, la distribution des temps internes de ľorganisme (fig 3) Ces résultats étaient à prévoir d’après les études anténeuies sur le librium, sur ľéthanol, sur les convulsions audiogéniques, sur le pentobarbital et sur ľéther hexaflurodiéthylique La discussion de ces travaux soulève la question de ľamélioration possible de la pratique de ľanesthésie, si ces données s’appliquent au rapport toxicité/théiapeutique des agents anesthésiques.
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Condensed from a paper presented at the Western Divisions’ Meeting, Canadian Anaesthetists’ Society, held in Edmonton, Alberta, in March 1962 Supported by grants from the U S Public Health Service [No H-1983 (C-7) and No 5-K6-GM-13981-03, NB-04531-02], The American Cancer Society (No E-155E), and the Graduate School of the University of Minnesota.