Abstract
AN agglutinin was found1–3 which interacted primarily with neoplastic cells: there were exceptions4 but not among virally transformed malignant cells. Although standard mother tissue cells did not agglutinate, all derivatives transformed by viruses agglutinated in similar conditions5, indicating that the ability of the tumour cell was acquired with viral transformation. The lines so far tested include polyoma virus transformed 3T3, adenovirus 12 transformed BHK and SV40 transformed 3T3 cells. The agglutinin was isolated and purified and, based on hapten inhibition, N-acetylglucosamine (GlcNac) was found to be part of the receptor site5,6.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ambrose, E. J., Dudgeon, J. A., Easty, D. M., and Easty, G. C., Exp. Cell Res., 24, 220 (1961).
Aub, J. C., Tieslau, C., and Lankester, A., Proc. US Nat. Acad. Sci., 50, 613 (1963).
Aub, J. C., Sanford, B. H., and Cote, M. N., Proc. US Nat. Acad. Sci., 54, 396 (1965).
Liske, R., and Franks, D., Nature, 217, 860 (1968).
Burger, M. M., and Goldberg, A. R., Proc. US Nat. Acad. Sci., 57, 359 (1967).
Burger, M. M., Symposium on the Developmental Biology of Neoplasia (edit. by Pitot, H. C.) (Amer. Cancer Society, in the press).
Hakomori, S., Koscielak, J., Bloch, K. J., and Jeanloz, R. W., J. Immunol., 98, 31 (1967).
Hakomori, S., and Murakami, W. T., Proc. US Nat. Acad. Sci., 59, 254 (1968).
Ohta, N., Pardee, A. B., McAuslan, B. R., and Burger, M. M., Biochim. Biophys. Acta, 158, 98 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BURGER, M. Isolation of a Receptor Complex for a Tumour Specific Agglutinin from the Neoplastic Cell Surface. Nature 219, 499–500 (1968). https://doi.org/10.1038/219499a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/219499a0
- Springer Nature Limited
This article is cited by
-
Two Component System for Surface Guided Reassociation of Animal Cells
Nature (1973)
-
A small intranuclear virus recovered from lymphatic tissue of a bovine with malignant lymphoma
Archiv f�r die gesamte Virusforschung (1973)
-
Surface molecular components of Ehrlich ascites tumour cells
Blut Zeitschrift für die Gesamte Blutforschung (1972)
-
Binding of 3H-Concanavalin A by Normal and Transformed Cells
Nature New Biology (1971)
-
“Pleiotypic Response”
Nature New Biology (1971)