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Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?

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Abstract

Fibrinogen from a patient with a blood coagulation disorder has an amino-acid substitution (arginine to serine) in the vicinity of the bond split by thrombin during normal blood coagulation.

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Authors and Affiliations

  1. New York Blood Center,

    M. BLOMBÄCK, B. BLOMBÄCK, E. F. MAMMEN & A. S. PRASAD

  2. the Departments of Physiology and Pharmacology, Pathology and Medicine, Wayne State University, School of Medicine, Detroit

    M. BLOMBÄCK, B. BLOMBÄCK, E. F. MAMMEN & A. S. PRASAD

  3. Veterans Administration Hospital, Allen Park, Michigan

    M. BLOMBÄCK, B. BLOMBÄCK, E. F. MAMMEN & A. S. PRASAD

  4. Department of Blood Coagulation Research, Karolinska Instituted Stockholm, Sweden

    M. BLOMBÄCK & B. BLOMBÄCK

Authors
  1. M. BLOMBÄCK
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  2. B. BLOMBÄCK
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  3. E. F. MAMMEN
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  4. A. S. PRASAD
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BLOMBÄCK, M., BLOMBÄCK, B., MAMMEN, E. et al. Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?. Nature 218, 134–137 (1968). https://doi.org/10.1038/218134a0

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  • DOI: https://doi.org/10.1038/218134a0

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