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Effect of Methionine Sulphoximine on Memory Transfer

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Abstract

METHIONINE sulphoximine influences the metabolism in the central nervous system in a number of different ways1. It affects the glutamine formation in the brain2, decreases the incorporation of phosphorus-32 in cytoplasmic ribonucleic acid3 and decreases the incorporation of methionine labelled with sulphur-35 into the brain proteins4. Methionine sulphoximine is an epileptogenic agent5 and in subconvulsive doses it blocks alimentary conditioned reflexes6. Injection of this compound causes pathological changes in the synapses where considerable quantities of the drug are found7.

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Authors and Affiliations

  1. Ghana Medical School, Accra, Ghana

    STANISLAV REINIŠ

  2. Institute of Biophysics, Charles University, Prague, Czechoslovakia

    JAROSLAV KOLOUŠEK

Authors
  1. STANISLAV REINIŠ
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  2. JAROSLAV KOLOUŠEK
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REINIŠ, S., KOLOUŠEK, J. Effect of Methionine Sulphoximine on Memory Transfer. Nature 217, 680–681 (1968). https://doi.org/10.1038/217680a0

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  • DOI: https://doi.org/10.1038/217680a0

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