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Inhibition by Adenosine Diphosphate of the Thrombocytopenia induced in Rabbits by Collagen or Thrombin

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Abstract

IT has been reported1 that in rabbits intravenous infusions or intramuscular injections of adenosine diphosphate (ADP) or adenosine triphosphate (ATP) reduce platelet adhesiveness as measured by glass bead columns. Because collagen and thrombin are implicated in thrombogenesis we thought it worth while to study their thrombocytopenic activities and any changes produced in them by exogenous ADP. In the experiments reported here, ADP markedly inhibited the thrombocytopenia induced by collagen or thrombin.

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References

  1. Busfield, Dorothy, and Tomich, E. G., Nature, 214, 1360 (1967).

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  2. Williamson, J. R., Prog. Med. Lab. Tech. (edit. by Baker, S.), 41 (1967).

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Authors and Affiliations

  1. Glaxo Research Limited, Greenford, Middlesex

    DOROTHY BUSFIELD & E. G. TOMICH

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  1. DOROTHY BUSFIELD
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  2. E. G. TOMICH
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BUSFIELD, D., TOMICH, E. Inhibition by Adenosine Diphosphate of the Thrombocytopenia induced in Rabbits by Collagen or Thrombin. Nature 217, 376–378 (1968). https://doi.org/10.1038/217376a0

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  • DOI: https://doi.org/10.1038/217376a0

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