Abstract
IN a recent paper OKunewick et al.1 reported that splenic erythropoiesis, denned as the 24 h uptake of iron-59 into the spleen, in mice lethally irradiated and grafted, depends on the source of the grafted cells. They found that grafting 106 bone marrow cells gave a greater uptake of iron-59 into the recipient spleen than grafting 106 spleen cells. In a second series of experiments, they found that 4 × 106 bone marrow cells grafted gave higher values than 4 × 107 spleen cells. They concluded that the relative erythropoietic activity of the spleen derived from spleen or bone marrow grafts is not a function of the number of cells administered and that the spleens are more erythro-poietically active if the animals have been grafted with bone marrow as opposed to spleen cells.
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References
OKunewick, J. P., Spencer, M. E., Glancy, G., Herrick, S. E., and Hennessy, T. G., Nature, 213, 302 (1967).
Fisher, R. A., and Yates, F., Statistical Tables for Biological, Agricultural and Medical Research (Oliver and Boyd, Edinburgh, 1943).
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LOUWAGIE, A., SCHOFIELD, R. & LAJTHA, L. Erythropoiesis in Lethally Irradiated Mice grafted with Bone Marrow or Spleen Cells. Nature 216, 370–371 (1967). https://doi.org/10.1038/216370a0
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DOI: https://doi.org/10.1038/216370a0
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