Abstract
THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying genetic mechanism. The aim of the present investigation was to throw more light on this problem, and to this end we have determined the NH2-terminal sequences of a large number of χ-chains and made a comparison of their structures.
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Gelotte, B., Flodin, P., and Killander, J., Arch. Biochem. Biophys., suppl. 1, 319 (1962).
Fahey, J. L., and Horbett, A. P., J. Biol. Chem., 234, 2645 (1959).
Fleischman, J. B., Pain, R. H., and Porter, R. R., Arch. Biochem. Biophys., suppl. 1, 174 (1962).
Cohen, S., and Gordon, S., Biochem. J., 97, 460 (1965).
Fahey, J. L., and McLaughlin, C., J. Immunol., 91, 484 (1963).
Edman, P., and Begg, G., European J. Biochem., 1, 80 (1967).
Gray, W. R., Dreyer, W. J., and Hood, L., Science, 155, 465 (1967).
Putnam, F. W., Titani, K., and Whitley, E., Proc. Roy. Soc., B, 166, 124 (1966).
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NIALL, H., EDMAN, P. Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins. Nature 216, 262–263 (1967). https://doi.org/10.1038/216262a0
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DOI: https://doi.org/10.1038/216262a0
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