Skip to main content
SpringerLink
Log in

Transformation of Primary Rat Embryo Cells by a Weakly Oncogenic Adenovirus—Type 3

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

ALTHOUGH human adenovirus types 3 (ref. 1), 7 (ref. 2), 12 (ref. 3), 18 (ref. 4), 14, 16, 21 (unpublished work of M. Pina and M. Green) and 31 (ref. 5) have been shown to be oncogenic in hamsters and, in some cases, mice and rats as well, in vitro transformation has been reported only for “highly oncogenic” types 12 (refs. 6–9) and 18 (unpublished results of Rafajko and Huebner). With primary rat embryo cells and a selective medium containing 0.1 mmolar calcium, a quantitative transformation system has been reported for adenovirus type 12 (ref. 9). It seemed that a similar system for the “weakly oncogenic” adenoviruses would be useful for quantitative studies of transformation by these two groups of adenoviruses, and this communication reports the transformation of rat cells by adenovirus type 3.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Huebner, R. J., Casey, M. J., Chanock, R. M., and Schell, K., Proc. US Nat. Acad. Sci., 54, 381 (1965).

    ADS  CAS  Google Scholar 

  2. Girardi, A. J., Hilleman, M. R., and Zusickey, R. E., Proc. Soc. Exp. Biol. and Med., 115, 1141 (1964).

    CAS  Google Scholar 

  3. Trentin, J. J., Yabe, Y., and Taylor, G., Science, 137, 835 (1962).

    ADS  CAS  PubMed  Google Scholar 

  4. Huebner, R. J., Rowe, W. P., and Lane, W. T., Proc. US Nat. Acad. Sci., 48, 2051 (1962).

    ADS  CAS  Google Scholar 

  5. Pereira, M. S., Pereira, H. G., and Clarke, S. K. R., Lancet, i, 21 (1965).

  6. Pope, J. H., and Rowe, W. P., J. Exp. Med., 120, 577 (1964).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. McBride, W. D., and Wiener, A., Proc. Soc. Exp. Biol. and Med., 115, 870 (1964).

    CAS  Google Scholar 

  8. Levinthal, J. D., and Petersen, W., Fed. Proc., 24, 174 (1965).

    Google Scholar 

  9. Freeman, A. E., Black, P. H., Wolford, R., and Huebner, R. J., J. Virol., 1, 362 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Eagle, H., Science, 122, 501 (1955).

    ADS  CAS  PubMed  Google Scholar 

  11. Eagle, H., Science, 130, 432 (1959).

    ADS  CAS  PubMed  Google Scholar 

  12. Rowe, W. P., Huebner, R. J., Hartley, J. W., Ward, T. G., and Parrott, R. H., Amer. J. Hyg., 61, 197 (1955).

    Google Scholar 

  13. Rowe, W. P., Hartley, J. W., and Huebner, R. J., Proc. Soc. Exp. Biol. and Med., 97, 465 (1958).

    CAS  Google Scholar 

  14. Hoggan, M. D., Blacklow, M. R., and Rowe, W. P., Proc. US Nat. Acad. Sci., 55, 1467 (1966).

    ADS  CAS  Google Scholar 

  15. Freeman, A. E., Hollinger, S., Price, P. J., and Calisher, C. H., Exp. Cell Res., 39, 259 (1965).

    CAS  PubMed  Google Scholar 

  16. Freeman, A. E., Calisher, C. H., Price, P. J., Turner, H. C., and Huebner, R. J., Proc. Soc. Exp. Biol. and Med., 122, 835 (1966).

    CAS  Google Scholar 

  17. Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T., Proc. US Nat. Acad. Sci., 50, 379 (1963).

    ADS  CAS  Google Scholar 

  18. Black, P. H., and White, B. J., J. Exp. Med., 125, 629 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Fujinaga, K., and Green, M., Proc. US Nat. Acad. Sci., 57, 806 (1967).

    ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Microbiological Associates, Inc., Bethesda, Maryland

    AARON E. FREEMAN & EUSTACE A. VANDERPOOL

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

    PAUL H. BLACK, HORACE C. TURNER & ROBERT J. HUEBNER

Authors
  1. AARON E. FREEMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. EUSTACE A. VANDERPOOL
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. PAUL H. BLACK
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. HORACE C. TURNER
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. ROBERT J. HUEBNER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

FREEMAN, A., VANDERPOOL, E., BLACK, P. et al. Transformation of Primary Rat Embryo Cells by a Weakly Oncogenic Adenovirus—Type 3. Nature 216, 171–173 (1967). https://doi.org/10.1038/216171a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216171a0

  • Springer Nature Limited

Search

Navigation