Abstract
Gregory and Tracy1 have isolated and with their colleagues2,3 have synthesized the antral hormone, gastrin, which has proved to be the most potent stimulant of gastric acid secretion. Tracy and Gregory4 showed in the dog that all the physiological actions of the heptadecapeptide gastrin molecule could be produced by the carboxy-terminal tetrapeptide amide try.met.asp.phe-NH2. Morley, Tracy and Gregory5 showed that several derivatives of this tetrapeptide also exhibited the full range of physiological activities of natural gastrin.
Similar content being viewed by others
References
Gregory, R. A., and Tracy, H. J., Gut, 5, 103 (1964).
Gregory, H., Hardy, P. M., Jones, D. S., Kenner, G. W., and Sheppard, R. C., Nature, 204, 931 (1964).
Anderson, V. C., Barton, M. A., Gregory, R. A., Hardy, P. M., Kenner, G. W., MacLeod, J. K., Preston, J., Sheppard, R. C., and Morley, J. S., Nature, 204, 933 (1964).
Tracy, H. J., and Gregory, R. A., Nature, 204, 935 (1964).
Morley, J. S., Tracy, H. J., and Gregory, R. A., Nature, 207, 1356 (1965).
Davidson, W. D., Lemmi, C. A. E., and Thompson, J. C., Proc. Soc. Exp. Biol. and Med., 121, 545 (1966).
Bentley, P. H., Kenner, G. W., and Sheppard, R. C., Nature, 209, 583 (1966).
Konturek, S., and Grossman, M. I., Gastroenterology, 50, 650 (1966).
Wormsley, K. G., Mahoney, M. P., and Ng, M., Lancet, i, 993 (1966).
Logan, C. J. H., and Connell, A. M., Lancet, i, 996 (1966).
Logan, C. J. H., Brick, I., and Roddie, I. C., Lancet, i, 999 (1966).
Davies, R. E., Biochem. J., 42, 609 (1948).
Forte, J. G., Adams, P. H., and Davies, R. E., Nature, 197, 874 (1963).
Alonso, D., and Harris, J. B., Amer. J. Physiol., 208, 18 (1965).
Shore, P. A., Burkhalter, A., and Cohn, V. H., J. Pharmacol. Exp. Therap., 127, 182 (1959).
Kahlson, G., Resengren, E., Svahn, P., and Thunberg, R., J. Physiol., 174, 400 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIDSON, W., LEMMI, C. & THOMPSON, J. Response of Isolated Bullfrog Gastric Mucosa to a Gastrin-like Pentapeptide. Nature 214, 595–596 (1967). https://doi.org/10.1038/214595a0
Issue Date:
DOI: https://doi.org/10.1038/214595a0
- Springer Nature Limited
This article is cited by
-
Histamine release by gastric stimulants
Nature (1975)
-
Action of caerulein and caerulein-like peptides on ?short-circuit current? and acid secretion in the isolated gastric mucosa of amphibians
Naunyn-Schmiedeberg's Archives of Pharmacology (1973)