Abstract
THE occurrence of lymphoreticular malignancy in patients with congenital agammaglobulinaemia1 or acquired hypogammaglobulinaemia2 is considered to suggest an interrelated response mediated by the thymus3. In spite of the wealth of experimental data about the part played by the thymus in leukaemogenesis4,5, lymphocytopoiesis6 and immunological competence7,8, the whole function of the thymus is not completely understood. There are patients with chronic lymphatic leukaemia who show evidence of autoimmune phenomena in the face of hypogammaglobulinaemia and marked susceptibility to infections9. A similar paradox is seen in thymoma-hypogammaglobulinaemic patients who may show “autoimmune” type antibodies while their normal immune response is virtually non-existent10,11.
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KENYON, A., WILLIAMS, R. Lymphatic Leukaemia associated with Dysproteinaemia in Ferrets. Nature 214, 1022–1024 (1967). https://doi.org/10.1038/2141022a0
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DOI: https://doi.org/10.1038/2141022a0
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