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Inhibition of the Extraneuronal Metabolism of Noradrenaline in the Isolated Heart by Adrenergic Blocking Agents

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Abstract

ADRENERGIC blocking agents inhibit the response of effector cells to noradrenaline and related amines1; several of these drugs also act as inhibitors of the uptake of noradrenaline into sympathetic nerves2,3. This communication describes a novel action of adrenergic blocking agents, the ability to inhibit the extraneuronal metabolism of noradrenaline in a peripheral tissue.

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References

  1. Nickerson, M., and Goodman, L. S., J. Pharmacol., 89, 167 (1947).

    CAS  Google Scholar 

  2. Hertting, G., Axelrod, J., and Whitby, L. G., J. Pharmacol., 134, 146 (1961).

    CAS  Google Scholar 

  3. Iversen, L. L., J. Pharm. Pharmacol., 17, 62 (1965).

    Article  CAS  Google Scholar 

  4. Iversen, L. L., Brit. J. Pharmacol., 21, 523 (1963).

    CAS  PubMed  Google Scholar 

  5. Whitby, L. G., Axelrod, J., and Weil-Malherbe, H., J. Pharmacol., 132, 193 (1961).

    CAS  Google Scholar 

  6. Kopin, I. J., Axelrod, J., and Gordon, E. J., J. Biol. Chem., 236, 2109 (1961).

    CAS  PubMed  Google Scholar 

  7. Axelrod, J., Albers, R. W., and Clemente, C. D., J. Neurochem., 5, 68 (1959).

    Article  CAS  Google Scholar 

  8. Wurtman, R. J., and Axelrod, J., Biochem. Pharmacol., 12, 1417 (1963).

    Article  CAS  Google Scholar 

  9. Kopin, I. J., and Gordon, E. K., J. Pharmacol., 138, 34 (1962).

    CAS  Google Scholar 

  10. Potter, L. T., Cooper, T., William, V. L., and Wolfe, D. E., Circulat. Res., 16, 468 (1965).

    Article  CAS  Google Scholar 

  11. Iversen, L. L., Glowinski, J., and Axelrod, J., J. Pharmacol., 151, 273, (1966).

    CAS  Google Scholar 

  12. Kopin, I. J., Pharmacol. Rev., 16, 179 (1964).

    CAS  Google Scholar 

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Author notes

  1. ARNOLD J. EISENFELD

    Present address: Department of Pharmacology, Yale University Medical School, New Haven, Connecticut

  2. LESLIE L. IVERSEN

    Present address: Department of Pharmacology, University of Cambridge,

Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

    ARNOLD J. EISENFELD, LAWRENCE KRAKOFF, LESLIE L. IVERSEN & JULIUS AXELROD

Authors
  1. ARNOLD J. EISENFELD
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  2. LAWRENCE KRAKOFF
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  3. LESLIE L. IVERSEN
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  4. JULIUS AXELROD
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EISENFELD, A., KRAKOFF, L., IVERSEN, L. et al. Inhibition of the Extraneuronal Metabolism of Noradrenaline in the Isolated Heart by Adrenergic Blocking Agents. Nature 213, 297–298 (1967). https://doi.org/10.1038/213297a0

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