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Action of Atomic Hydrogen on Ribonuclease in Aqueous Solution

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Abstract

Atomic hydrogen seems to react with ribonuclease in aqueous solution, not by attacking the molecule at random, but by reacting with specific amino-acids in the enzyme. It seems to have a special affinity for aromatic and sulphur-containing amino-acids, even though these may be some way from the surface of the enzyme.

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References

  1. Navon, G., and Stein, G., J. Phys. Chem., 69, 1384, 1389 (1965) and references therein.

    Article  CAS  Google Scholar 

  2. Navon, G., and Stein, G., Israel J. Chem., 2, 151 (1964).

    Article  CAS  Google Scholar 

  3. Mee, L. K., Navon, G., and Stein, G., Nature, 204, 1056 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Czapski, G., Frohwirth, N., and Stein, G., Nature, 207, 1191 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Czapski, G., and Stein, G., Israel J. Chem., 2, 15 (1964).

    Article  CAS  Google Scholar 

  6. Czapski, G., and Stein, G., J. Phys. Chem., 64, 219 (1960).

    Article  CAS  Google Scholar 

  7. Navon, G., and Stein, G., J. Phys. Chem., 70, 3630 (1966).

    Article  CAS  Google Scholar 

  8. Mee, L. K., Navon, G., Stein, G., Biochim. Biophys. Acta, 104, 151 (1965).

    Article  CAS  Google Scholar 

  9. Anfinsen, C. B., Redfield, R. R., Choate, W. L., Page, J., and Carroll, W. R., J. Biol. Chem., 207, 201 (1954).

    CAS  Google Scholar 

  10. Ellman, G. L., Arch. Biochem. Biophys., 82, 70 (1959).

    Article  CAS  Google Scholar 

  11. Scheraga, H. A., and Rupley, J. A., Adv. Enzymol., 24, 161 (1962).

    CAS  Google Scholar 

  12. Braams, E., in Pulse Radiolysis, 171 (Academic Press, New York, 1965); Radiat. Res., 27, 319 (1966).

    Google Scholar 

  13. Smith, T. W., and Adelstein, S. J., Radiat. Res., 24, 119 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Mee, L. K., Radiat. Res., 21, 501 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Anfinsen, C. B., J. Polymer Sci., 49, 31 (1961); White, F. H., jun., J. Biol. Chem., 236, 1353 (1961).

    Article  ADS  CAS  Google Scholar 

  16. Stein, G., Princeton Univ. Conf. Chemistry of Sulfides, June, 1966.

  17. Stein, G., and Stiassny, G., Nature, 176, 734 (1955); Stein, G., and Swallow, A. J., J. Chem. Soc., 306 (1958); Paiss, Y., and Stein, G., J. Chem. Soc., 2905 (1958).

    Article  ADS  CAS  Google Scholar 

  18. Smyth, D. G., Stein, W. H., and Moore, S., J. Biol. Chem., 238, 227 (1963); Stein, W. H., Israel J. Med. Sci., 1, 1229 (1965).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiotherapeutics, University of Cambridge,

    BARBARA E. HOLMES

  2. Department of Physical Chemistry, Hebrew University, Jerusalem, Israel

    GIL NAVON & GABRIEL STEIN

Authors
  1. BARBARA E. HOLMES
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  2. GIL NAVON
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  3. GABRIEL STEIN
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HOLMES, B., NAVON, G. & STEIN, G. Action of Atomic Hydrogen on Ribonuclease in Aqueous Solution. Nature 213, 1087–1091 (1967). https://doi.org/10.1038/2131087a0

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