Abstract
METHYLHYDRAZINE derivatives were originally introduced as a new class of anti-tumour agents1. Since then, as with other cytotoxic drugs, immunosuppressive effects have also been demonstrated2,3. In an investigation of the pharmacological susceptibility of the primary skin homograft reaction, it became increasingly clear that the methylhydrazine derivatives were among the few agents which provided a definite prolongation of graft survival in mice4. The present experiments were carried out to determine the effect of these compounds on the survival of second-set skin homografts.
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References
Bollag, W., and Grunberg, E., Experientia (Basle), 19, 130 (1963).
Bollag, W., Experientia (Basle), 19, 304 (1963).
Floersheim, G. L., Experientia (Basle), 19, 546 (1963).
Floersheim, G. L., Helv. Physiol. Acta, 22, 241 (1964).
Billingham, R. E., and Medawar, P. B., J. Exp. Biol., 28, 385 (1951).
d'Alessandri, H., Keel, H. J., Bollag, W., and Martz, G., Schw. Med. Wschr., 93, 1018 (1963).
Mathé, G., Schweissguth, O., Schneider, M., Amiel, J. L., Berumen, L., Brulé, G., Cattan, A., and Schwarzenberg, L., Lancet, ii, 1077 (1963).
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FLOERSHEIM, G. Effect of Methylhydrazine Derivatives on the Survival of Second-set Skin Homografts. Nature 211, 638–639 (1966). https://doi.org/10.1038/211638a0
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DOI: https://doi.org/10.1038/211638a0
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