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Tumour inhibitory effects of a new class of cytotoxic agents: Methylhydrazine derivatives

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Zusammenfassung

Die tumorhemmende Wirkung einer neuen Klasse von Cytostatica (Methylhydrazinderivate) wird beschrieben. Das Wachstum des Ehrlich-Carcinoms in solider und ascitischer Form, des Crocker Sarkoms S 180, des Walker-Carcinosarkoms 256 und des Uterus-Epithelioms T 8 wird deutlich gehemmt. 1-Methyl-2-p-(isopropylcarbamoyl)benzyl-hydrazin-hydrochlorid (I) und 1-Methyl-2-p-allophanoylbenzyl-hydrazin-hydrobromid (II) zeichnen sich durch besonders starke cytostatische Aktivität aus.

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References

  1. P. Zeller et al., Exper.19, 129 (1963).

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  3. A. Rutishauser andW. Bollag, Exper.19, 131 (1963).

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Authors and Affiliations

  1. Medizinische Forschungsabteilung, F. Hoffmann-La Roche & Co. AG., Basel, Switzerland

    W. Bollag & E. Grunberg

  2. Medical Research Department, Hoffmann-La Roche Inc., Nutley, New Jersey, U.S.A.

    W. Bollag & E. Grunberg

Authors
  1. W. Bollag
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  2. E. Grunberg
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Bollag, W., Grunberg, E. Tumour inhibitory effects of a new class of cytotoxic agents: Methylhydrazine derivatives. Experientia 19, 130–131 (1963). https://doi.org/10.1007/BF02171589

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  • DOI: https://doi.org/10.1007/BF02171589

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