Skip to main content
SpringerLink
Log in

Antigenicity of Conjugates of Arsanilic Acid in Inbred Guinea-pigs

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

RECENT investigations have shown that the genetic constitution of the host is of critical importance as regards the immune response to hapten poly-L-lysine conjugates1,2, random linear copolymers3 and reactivity in certain hyper-sensitivity phenomena such as experimental allergic encephalomyelitis4 and thyroiditis5. This information was obtained with guinea-pigs of inbred strains 2 and 13 which had been demonstrated by Bauer in 1958 (ref. 6) to be histocompatible. Investigations on arsanilic acid conjugates of amino-acid polymers7,8 have shown that these conjugates are antigenic in random-bred guinea-pigs. Accordingly, experiments were designed to assess the immune response of the inbred strains 2 and 13 to arsanilic acid conjugates of poly-L-lysine (ars-L) and poly-L-glutamic L-lysine L-tyrosine (ars-GLT).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Levine, B. B., Ojeda, A., and Benacerraf, B., J. Exp. Med., 118, 953 (1963).

    Article  CAS  Google Scholar 

  2. Schlossman, S. F., Yaron, A., Ben-Efraim, S., and Sober, H. A., Biochemistry, 4, 1638 (1965).

    Article  CAS  Google Scholar 

  3. Ben-Efraim, S., and Maurer, P. H. (in preparation).

  4. Stone, S. H., Intern. Arch. Allergy, 20, 193 (1962).

    Article  CAS  Google Scholar 

  5. McMaster, P. R. B., Lerner, E. M., and Mueller, P. S., Science, 147, 157 (1965).

    Article  ADS  CAS  Google Scholar 

  6. Bauer, jun., J. A., Ann. N.Y. Acad. Sci., 73, 663 (1958).

    Article  ADS  Google Scholar 

  7. Leskowitz, S., J. Exp. Med., 117, 909 (1963).

    Article  CAS  Google Scholar 

  8. Benacerraf, B., Ojeda, A., and Maurer, P. H., J. Exp. Med., 118, 945 (1963).

    Article  CAS  Google Scholar 

  9. Ovary, Z., Prog. Allergy, 5, 459 (1958).

    CAS  Google Scholar 

  10. Levine, B. B., Ojeda, A., and Benacerraf, B., Nature, 200, 544 (1963).

    Article  ADS  CAS  Google Scholar 

  11. Arquilla, E. B., and Finn, J., J. Exp. Med., 122, 271 (1965).

    Article  Google Scholar 

Download references

Author information

Author notes

  1. SHLOMO BEN-EFRAIM: Visiting scientist from Israel Institute for Biological Research, P.O.B. 19, Ness-Ziona, Israel.

Authors and Affiliations

  1. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

    SHLOMO BEN-EFRAIM & SIDNEY LESKOWITZ

  2. Massachusetts General Hospital, Boston, Massachusetts

    SHLOMO BEN-EFRAIM & SIDNEY LESKOWITZ

Authors
  1. SHLOMO BEN-EFRAIM
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SIDNEY LESKOWITZ
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BEN-EFRAIM, S., LESKOWITZ, S. Antigenicity of Conjugates of Arsanilic Acid in Inbred Guinea-pigs. Nature 210, 1068–1069 (1966). https://doi.org/10.1038/2101068a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2101068a0

  • Springer Nature Limited

This article is cited by

Search

Navigation