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On the Shape of the Dose-response Curve for HeLa Cells cultured in vitro and exposed to Gamma-radiation

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Abstract

PROGRESS in theoretical radiobiology depends very largely on the interpretation of dose-response curves; nowadays, interest is being focused on the reproductive survival of mammalian cells. Unfortunately research workers measure, not survival ‘curves’, but a limited number of discrete points. These data, even if free from artefacts which would render them meaningless, have such limited statistical significance that it is often possible to fit more than one mutually exclusive theoretical curve through them.

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Authors and Affiliations

  1. Radiotherapy Department, The Churchill Hospital, Oxford

    JOEL S. BEDFORD & ERIC J. HALL

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  1. JOEL S. BEDFORD
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  2. ERIC J. HALL
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BEDFORD, J., HALL, E. On the Shape of the Dose-response Curve for HeLa Cells cultured in vitro and exposed to Gamma-radiation. Nature 209, 1363–1364 (1966). https://doi.org/10.1038/2091363a0

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