Skip to main content
SpringerLink
Log in

Liver Metabolism of Anticholinesterase Compounds in Live Rats : Relation to Toxicity

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE insecticide ‘Isolan’ (1-isopropyl-3-methyl-5-pyrazolyl dimethylcarbamate) is more toxic to rats by the dermal than by the oral route1. This finding is interesting, because the opposite is true of most compounds. It was not known whether the unexpected difference in the toxicity of ‘Isolan’ by the two routes was caused by detoxification in the intestinal lumen, poor absorption from the gastrointestinal tract, detoxification in the liver, unusually efficient percutaneous absorption, or some other mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gaines, T. B., Toxicol. App. Pharmacol., 2, 88 (1960).

    Article  CAS  Google Scholar 

  2. Ross, P. L. E., and Rappaport, A. M., Nature, 188, 326 (1960).

    Article  ADS  CAS  Google Scholar 

  3. Bollman, J. L., J. Lab. Clin. Med., 33, 1348 (1948).

    CAS  PubMed  Google Scholar 

  4. Tullner, W. W., and Hertz, R., Endocrinology, 66, 494 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Toxicology Section, Technology Branch, Communicable Disease Center, U.S. Department of Health, Education and Welfare, Atlanta, Georgia

    THOMAS B. GAINES, WAYLAND J. HAYES JUN. & RALPH E. LINDER

Authors
  1. THOMAS B. GAINES
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. WAYLAND J. HAYES JUN.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. RALPH E. LINDER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GAINES, T., HAYES, W. & LINDER, R. Liver Metabolism of Anticholinesterase Compounds in Live Rats : Relation to Toxicity. Nature 209, 88–89 (1966). https://doi.org/10.1038/209088a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/209088a0

  • Springer Nature Limited

This article is cited by

Search

Navigation