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Pronethalol-induced Reversal of Adrenergic Vasodepression

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Abstract

SEVERAL substances have been described as causing reversal of the adrenergic vasodepression observed after blockade of α-receptors, adrenaline reacquiring its usual pressor action. However, when tested in animals treated with long-acting, potent and almost irreversible adrenergic blocking drugs like the β-haloalkylamines dibenamine and phenoxybenzamine, only some pressor agents as, for example, ephedrine, vasopressin, methoxamine, phenylephrine and barium chloride1–3 provoke with regularity negation of adrenergic blockade. In an attempt to investigate the mechanism of this anti-adrenolytic action further, we used the β-adrenergic blocking drug, pronethalol (‘Nethalide’, ‘Alderlin’, ref. 4) and made the unexpected finding that it also causes restoration of the pressor action of adrenaline, when injected after blockade of α-receptors.

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Authors and Affiliations

  1. Laboratório de Farmacologia, Faculdade de Medicina, Porto, Portugal

    M. GONÇALVES MOREIRA & W. OSSWALD

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  1. M. GONÇALVES MOREIRA
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  2. W. OSSWALD
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MOREIRA, M., OSSWALD, W. Pronethalol-induced Reversal of Adrenergic Vasodepression. Nature 208, 1006–1007 (1965). https://doi.org/10.1038/2081006a0

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