Abstract
MAGNESIUM activates many enzymes in vitro, but very few disturbances in enzymatic activity have been demonstrated during magnesium deficiency in vivo1. The alkaline phosphatases from various mammalian tissues are among the enzymes known to be activated by magnesium in isolated systems. This communication reports investigations of the effect of magnesium deficiency on plasma alkaline phosphatase activity in the rat.
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References
Wacker, W. E. C., and Vallee, B. L., New Eng. J. Med., 259, 431 (1958).
Heaton, F. W., and Anderson, C. K., Clin. Sci., 28, 99 (1965).
King, E. J., and Wootton, I. D. P., Micro-Analysis in Medical Biochemistry, 83 (J. and A. Churchill, London, 1959).
Dawson, J. B., and Heaton, F. W., Biochem. J., 80, 99 (1961).
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HEATON, F. Effect of Magnesium Deficiency on Plasma Alkaline Phosphatase Activity. Nature 207, 1292–1293 (1965). https://doi.org/10.1038/2071292b0
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DOI: https://doi.org/10.1038/2071292b0
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