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Autoradiographic Evaluation of the Distribution of N,N′-bis(Thiazole)-2,7- fluorene-disulphonamide-35S in Organs of Rats

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Abstract

DETERMINATION of the diagnostic value of N,N′-bis (thiazole)-2,7-fluorene-disulphonamide-35S (TFDS-35) revealed some differences in its distribution in the tissues of rats bearing Walker carcinosarcoma as compared with tumour-free animals, regarding the TFDS-35 level in red blood cells, blood plasma, liver, spleen, kidneys and urine1. Furthermore, the tumour tissue showed a relatively high concentration of the disulphonamide. The present investigation was aimed at explaining these differences by histological and autoradiographic examination of selected organs and tumour tissue of rats.

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References

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Authors and Affiliations

  1. Department of Pathological Anatomy, Al. Przybyszewskiego 49

    KAZIMIERZ KASPRZAK, DANUTA MALEJKA & PRZEMYSLAW GABRYEL

  2. Department of Pharmaceutical Chemistry, Medical Academy, ul. Grunwaldzka 6, Poznań, Poland

    KAZIMIERZ KASPRZAK, DANUTA MALEJKA & PRZEMYSLAW GABRYEL

Authors
  1. KAZIMIERZ KASPRZAK
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  2. DANUTA MALEJKA
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  3. PRZEMYSLAW GABRYEL
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KASPRZAK, K., MALEJKA, D. & GABRYEL, P. Autoradiographic Evaluation of the Distribution of N,N′-bis(Thiazole)-2,7- fluorene-disulphonamide-35S in Organs of Rats. Nature 206, 1266–1267 (1965). https://doi.org/10.1038/2061266a0

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  • DOI: https://doi.org/10.1038/2061266a0

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