Abstract
Dinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of >95 %) was used to determine its in vivo biodistribution in Sprague-Dawley rats. Gamma scintigraphs were performed over a period of 48 h and final radioactivity measurements of harvested organs of the test animals after termination was performed at 2, 4 and 48 h. The study successfully showed the biodistribution of the gold complex, with the highest uptake of the compound being observed in the lungs, liver and spleen.
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Acknowledgments
The authors would like to thank the Nuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI), a national technology platform developed and managed by the South African Nuclear Energy Corporation (Necsa) and funded by the Department of Science and Technology. We also thank Biomed (Mintek) for financial support and the University of the Free State (UFS) for use of their facilities. We would also like to thank Prof. James Darkwa and Dr Frankline Keter for initial work on the compound.
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Kriel, F.H., Szucs, Z., van Staden, J.A. et al. Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue. J Radioanal Nucl Chem 303, 1949–1954 (2015). https://doi.org/10.1007/s10967-014-3816-4
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DOI: https://doi.org/10.1007/s10967-014-3816-4