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Effect of Trypsin on Resting Potential of Frog Muscle

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Abstract

PAST work on the exposure of cells to protease has indicated either that the proteins on the outer surface of the cell do not contribute to the physiological properties of the membrane or that they are not available to enzymatic action. The external application of proteases to squid, lobster, or frog axons does not seem to alter the resting potential or the excitability of these cells1–4. Erythrocytes exposed to trypsin for up to 24 h show no change in permeability compared with normal cells5. However, external application of protease has been shown to produce injury potentials in muscle2.

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Authors and Affiliations

  1. Department of Physiology, University of Chicago,

    D. HOLTZMAN & D. AGIN

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  1. D. HOLTZMAN
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  2. D. AGIN
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HOLTZMAN, D., AGIN, D. Effect of Trypsin on Resting Potential of Frog Muscle. Nature 205, 911–912 (1965). https://doi.org/10.1038/205911a0

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