Abstract
AGGREGATION of platelets in the presence of adenosine diphosphate (ADP) appears to be important in hæmostasis and in the genesis of platelet thrombosis. There is evidence that this reaction is common to platelet clumping induced by a variety of stimuli, including collagen, adrenaline, long-chain fatty acids, and perhaps weak solutions of thrombin. Although this phenomenon is under investigation in many laboratories, the mechanism by which ADP causes platelet aggregation is largely unknown. Certain inhibitors of platelet clumping have been described (for example, inhibition of thrombin-induced platelet aggregation by heparin1 or of ADP by adenosine2), and investigation of the inhibitory reaction has afforded some insight into the underlying process.
Similar content being viewed by others
References
Zucker, M. B., and Borelli, J., J. App. Physiol., 14, 575 (1959).
Born, G. V. R., and Cross, M. J., J. Physiol., 166, 29P (1963).
Born, G. V. R., J. Physiol., 162, 67P (1962).
Lineweaver, H., and Burk, D., J. Amer. Chem. Soc., 56, 658 (1934).
Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).
Shermer, R. W., Mason, R. G., Wagner, R. H., and Brinkhous, K. M., J. Exp. Med., 114, 905 (1961).
Bounameaux, Y., Rev. franc. d'etudes clin. et biol., 4, 54 (1959).
Käzer-Glanzmann, R., and Lüscher, E. F., Thromb. Diath. Hœem., 7, 480 (1962).
Grette, K., Acta Physiol. Scand., 56, Supp. 195 (1962).
Schwert, G. W., and Takenaka, Y., Biochim. Biophys. Acta, 16, 570 (1955).
Salzman, E. W., J. Lab. Clin. Med., 62, 724 (1963).
Nilsson, I. M., Blombäck, M., Jorpes, E., Blombäck, B., and Johansson, S. A., Acta Med. Scand., 159, 179 (1957).
Salzman, E. W., and Britten, A., Fed. Proc., 23, 239 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SALZMAN, E., CHAMBERS, D. Inhibition of ADP-induced Platelet Aggregation by Substituted Amino-acids. Nature 204, 698–700 (1964). https://doi.org/10.1038/204698b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/204698b0
- Springer Nature Limited
This article is cited by
-
Multiple Specificity of Thrombin for Synthetic Substrates
Nature (1967)
-
Untersuchungen �ber den Einflu� von Papaverin auf Reaktionen der Blutpl�ttchen
Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie (1967)
-
Plasma Co-factors in Adenosine Diphosphate-induced Aggregation of Human Platelets
Nature (1965)
-
Comparative Effectiveness of Adenosine Analogues as Inhibitors of Blood-Platelet Aggregation and as Vasodilators in Man
Nature (1965)
-
Incorporation by Blood Platelets of Adenosine Diphosphate labelled with Carbon-14
Nature (1965)