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Exaltation of Toxicity of Sympathomimetic Amines by Thyroxine

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Abstract

VARIOUS factors are known to influence the toxicity of sympathomimetic amines in mice, especially ambient temperature1,2, aggregation1,2 and psychotropic drugs2–5. Halpern et al.6 reported recently that pretreatment with thyroxine considerably aggravated the central nervous stimulation and mortality induced by amphetamine in aggregated mice. Here, evidence is presented to show that pretreatment with thyroid hormone also markedly increased the toxicity of sympathomimetic amines in solitary mice.

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Authors and Affiliations

  1. Chaire de Médecine Expérimentale du Collège de France, Paris, 5e

    BERNARD N. HALPERN, CAROLA DRUDI-BARACCO & DENISE BESSIRARD

Authors
  1. BERNARD N. HALPERN
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  2. CAROLA DRUDI-BARACCO
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  3. DENISE BESSIRARD
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HALPERN, B., DRUDI-BARACCO, C. & BESSIRARD, D. Exaltation of Toxicity of Sympathomimetic Amines by Thyroxine. Nature 204, 387–388 (1964). https://doi.org/10.1038/204387a0

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