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Combination Chemotherapy with Actinomycin D and Ribonuclease : an Example of Complementary Inhibition

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Abstract

Two mechanisms have been suggested by which combinations of drugs may depress the intracellular availability of a given metabolite to a level that becomes limiting for cell survival. Potter1 has applied the term sequential inhibition to the action of two or more inhibitors on different enzymes in a limited portion of a multi-enzyme sequence (equation 1), and Elion, Singer and Hitchings2 have denoted as concurrent blockade the simultaneous retardation, by two or more agents, of alternate biochemical routes to the same end-product (equation 2).

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References

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Authors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

    ALAN C. SARTORELLI

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  1. ALAN C. SARTORELLI
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SARTORELLI, A. Combination Chemotherapy with Actinomycin D and Ribonuclease : an Example of Complementary Inhibition. Nature 203, 877–878 (1964). https://doi.org/10.1038/203877a0

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