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Human Pancreas-specific Isoantigens

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Abstract

PANCREAS-SPECIFIC isoantigens have been detected in rabbits1 and rhesus monkeys2 following experimental isoimmunization. It has also been reported that isoantibodies and autoantibodies occur in the sera of patients with various types of pancreatic disease3–5. Attempts were made in this laboratory to confirm the findings in man using the same techniques of agar-precipitation and indirect hæmagglutination. Difficulty was experienced since normal serum or globulin often gave precipitin lines in agar. Any specific effect from the interaction of serum from patients with pancreatic disease and human pancreas extracts could therefore not be distinguished from nonspecific precipitation.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina

    RICHARD S. METZGAR

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  1. RICHARD S. METZGAR
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METZGAR, R. Human Pancreas-specific Isoantigens. Nature 203, 660–661 (1964). https://doi.org/10.1038/203660a0

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