Abstract
THE phenomenon known as ‘gene conversion’1, which results in the production of tetrads in which a pair of alleles segregates in a 3 : 1 ratio, instead of the usual 2 : 2 ratio, has been explained on the basis of a copy-choice theory2. Such an explanation is unacceptable unless the conservative replication of chromatids, at least in part, is also hypothesized3. It is generally accepted that both the DNA double helix4 and chromatids replicate semi-conservatively5. However, there exists evidence which suggests that the DNA double helix may replicate conservatively6.
Similar content being viewed by others
References
Lindegren, C. C., J. Genet., 51, 625 (1953).
Case, M. E., and Giles, N. H., Cold Spring Harbor Symp. Quant. Biol., 23, 119 (1958).
Pritchard, R. H., in Microbial Genetics, edit. by Hayes, W., and Clowes, R. C. (Cambridge Univ. Press, London, 1960).
Meselson, M., and Stahl, F. W., Proc. U.S. Nat. Acad. Sci., 44, 671 (1958).
Taylor, J. H., Amer. Nat., 91, 209 (1957).
Cavalieri, L. F., and Rosenberg, B. H., Biophys. J., 1, 323 (1961).
Gear, J. R., and Spenser, I. D., Canad. J. Chem., 41, 783 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MARIMUTHU, K., THRELKELD, S. Tetrad Analysis by Autoradiography. Nature 203, 101–102 (1964). https://doi.org/10.1038/203101a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/203101a0
- Springer Nature Limited