Abstract
WHEN describing the highly specific action of adenosine diphosphate on the aggregation and adhesiveness of human platelets, it was reported that deoxyadenosine diphosphate was the only other nucleotide which exhibited this effect. On a weight basis this nucleotide had only 0.3 per cent of the activity of ADP. However, as a substance with biological activity, the amount required (7 µg/ml.) for aggregation was still very small1.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).
Born, G. V. R., and Cross, M. J., J. Physiol., 168, 178 (1963).
Clayton, S., Born, G. V. R., and Cross, M. J., Nature, 200, 138 (1963).
Regoli, D., and Clark, V., Nature, 200, 546 (1963).
Born, G. V. R., Nature, 194, 926 (1962).
Kaczka, A. K., Trenner, N. R., Arison, B., Walker, R. W., and Folkers, K., Biochem. Biophys. Res. Comm., 14, 456 (1964).
Klenow, H., Biochim. Biophys. Acta, 76, 347 (1963).
Klenow, H., and Fredriksen, S., Biochim. Biophys. Acta, 52, 384 (1961).
Stevens, M. A., Smith, H. V., and Brown, G. B., J. Amer. Chem. Soc., 81, 1734 (1959).
Hellem, A. J., Nord. Med., 66, 1490 (1961).
Ödegaard, A. E., Skålhegg, B. A., and Hellem, A. J., Thrombos. Diathes. hæmorrh. (in the press).
Hellem, A. J., Ödegaard, A. E., and Skålhegg, B. A., to be presented at the Tenth Cong. Intern. Soc. Hæmatology, Stockholm (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GAARDER, A., LALAND, S. Hypothesis for the Aggregation of Platelets by Nucleotides. Nature 202, 909–910 (1964). https://doi.org/10.1038/202909a0
Issue Date:
DOI: https://doi.org/10.1038/202909a0
- Springer Nature Limited
This article is cited by
-
Thermo-induced structural rearrangements of platelet membranes by the action of an inductor and inhibitors of aggregation
Bulletin of Experimental Biology and Medicine (1993)
-
Transformationsvorg�nge in der Fr�hphase der Entstehung des arteriellen Thrombus
Virchows Archiv A Pathological Anatomy and Histology (1980)
-
Biochemische Prozesse bei der Ausl�sung der Blutgerinnung durch Kollagen
Klinische Wochenschrift (1974)
-
Changes in the Adenylate Energy Charge in Human Blood Platelets induced by Adenosine Diphosphate
Nature New Biology (1973)