Skip to main content
SpringerLink
Log in

Effect of Adenosine Diphosphate on Circulating Platelets in Man

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IN 1960 Hellem1 reported that platelet adhesiveness in vitro was increased by a dialysable substance derived from red cells, and that he had observed transient thrombocytopenia in rabbits after intravenous injections of this material. The active fraction was afterwards identified as adenosine diphosphate (ADP)2. The specific aggregation of platelets in vitro by ADP, and the inhibition of this action by adenosine, its monophosphate (AMP) and its triphosphate (ATP), have been demonstrated by other workers3,4. It has also been shown that when thrombin is added to platelet suspensions free of red cells, sufficient ADP is released by platelets themselves to account for their subsequent aggregation5,6.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hellem, A. J., Scand. J. Clin. Lab. Invest., 12, Supp. 51 (1960).

  2. Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).

    Article  ADS  CAS  Google Scholar 

  3. Born, G. V. R., Nature, 194, 927 (1962).

    Article  ADS  CAS  Google Scholar 

  4. O'Brien, J. R., J. Clin. Path., 15, 446 (1962).

    Article  CAS  Google Scholar 

  5. Grette, K., Acta physiol. Scand., 56, Supp. 195 (1962).

  6. Käser-Glanzmann, R., and Lüscher, E. F., Thromb. Diath. Hœm. (Stuttgart), 7, 480 (1962).

  7. Honour, A. J., and Mitchell, J. R. A., Nature, 197, 1019 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Born, G. V. R., and Cross, M. J., Nature, 197, 974 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Regoli, D., and Clark, V., Nature, 200, 546 (1963).

    Article  ADS  CAS  Google Scholar 

  10. Davey, M. G., and Lander, H., Austral. J. Exp. Biol. Med. Sci., 41, 581 (1963).

    Article  CAS  Google Scholar 

  11. Greenfield, A. D. M., J. Physiol. (Lond.), 123, 62, P(1954).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Adelaide, South Australia

    M. G. DAVEY & HARRY LANDER

Authors
  1. M. G. DAVEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HARRY LANDER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DAVEY, M., LANDER, H. Effect of Adenosine Diphosphate on Circulating Platelets in Man. Nature 201, 1037–1039 (1964). https://doi.org/10.1038/2011037c0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2011037c0

  • Springer Nature Limited

This article is cited by

Search

Navigation