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Effect of Basic Dyes on Host-cell Reactivation of Ultra-violet-irradiated Phage

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Abstract

STRAINS of bacteria can be divided into two classes depending on their ability to effect dark repair of ultraviolet-induced damage to phage DNA1. Those strains which manifest this ability are hcr+ (host-cell reactivation positive) and those which show a reduced ability are hcr− (ref. 2). Since post-irradiation exposure of bacteria to basic dyes reduces the ability to repair damage to their own DNA, presumably by hindering replication3, a similar effect of these dyes on irradiated phage DNA might be expected. Under these conditions, hcr+ strains would then resemble hcr− strains. This possibility has been confirmed.

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Authors and Affiliations

  1. Radiological Research Laboratory, Department of Radiology, Columbia University, New York

    ROSE R. FEINER & RUTH F. HILL

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  1. ROSE R. FEINER
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  2. RUTH F. HILL
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FEINER, R., HILL, R. Effect of Basic Dyes on Host-cell Reactivation of Ultra-violet-irradiated Phage. Nature 200, 291–293 (1963). https://doi.org/10.1038/200291a0

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