Skip to main content
SpringerLink
Log in

Isolation of a Radiation-Mortality Reducing Factor from Spleen

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE radiation-mortality reducing action of cell-free extracts obtained from spleens of mice, guinea pigs and dogs has been demonstrated in a series of previous investigations1,2. The extraction procedure used for preparing spleen extracts has been described elsewhere2,3. The observation that homologous, as well as the heterologous, spleen extracts were equally effective suggests that a common chemical entity (or entities) may be the therapeutic agent4. This is a preliminary report of the isolation and characterization of fractions obtained from dog spleen extracts which contain this factor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jacobson, L. O., Cancer Res., 12, 315 (1952).

    CAS  PubMed  Google Scholar 

  2. Ellinger, F., Amer. J. Roentgen., Rad. Therap. and Nuc. Med., 87, 547 (1962).

    CAS  Google Scholar 

  3. Ellinger, F., and Lindsley, B. F., Arch. Int. Pharmacodynamie et de Therapie, 132, 310 (1961).

    CAS  Google Scholar 

  4. Ellinger, F., and Strike, T. A., Acta Hœmatologica, 26, 117 (1961).

    Article  CAS  Google Scholar 

  5. Ashikawa, J. K., and Anderson, O. K., Rad. Res., 13, 99 (1960).

    Article  CAS  Google Scholar 

  6. Ferris, T. G., Easterling, R. G., and Budd, R. G., Blood, 19, 479 (1962).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Naval Medical Research Institute, National Naval Medical Center, Bethesda, 14, Maryland

    SAM KATZ & F. ELLINGER

Authors
  1. SAM KATZ
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. ELLINGER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KATZ, S., ELLINGER, F. Isolation of a Radiation-Mortality Reducing Factor from Spleen. Nature 197, 397–399 (1963). https://doi.org/10.1038/197397b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/197397b0

  • Springer Nature Limited

This article is cited by

Search

Navigation