Effect of Tri-iodothyronine on Ethanol Metabolism in the Dog

Abstract

Kalant, Sereny and Charlebois¹ have recently reviewed the literature pertaining to the effectiveness of tri-iodothyronine in the treatment of acute alcoholic intoxication. Contrary to several earlier studies by other investigators, Kalant et al. observed no effect in patients in either the rate of disappearance of blood alcohol or in percentage improvement in the performance of a letter-marking test following treatment with tri-iodothyronine. Since these investigations on man yielded results similar to those which we had obtained in dogs it seemed of interest to report our findings in intact dogs and in rat liver homogenates.