Abstract
Glutamate dehydrogenase (GLDH), sorbitol dehydrogenase (SDH), 5'-nucIeotidase (5'-ND) and cholin esterase (CHE) were determined in the sera of 37 dogs with various liver diseases. The values for these parameters were compared with the values for aspartate and alanin aminotransferase (ASAT, ALAT), alkaline phosphatase (ALP), γ-glutamyl transferase (γ-GT) and albumin (ALB). GLDH was found to be the most sensitive enzyme parameter (sensitivity 92 %), its values also reflecting the degree of liver cell necrosis well. Next in sensitivity followed ASAT and ALP. SDH values were correlated to ALAT values but had a low sensitivity (43 %). 5'-ND discriminated markedly better between biliary tract disturbance and other lesions than ALP and somewhat better than γ-GT. CHE had a wide reference range, low sensitivity, and was not correlated to ALB. Single determinations of CHE may thus not be of diagnostic value in dogs.
Sammendrag
Glutamatdehydrogenase (GLDH), sorbitoldehydrogenase (SDH), 5'-nukleotidase (5'-ND) og cholinesterase (CHE) ble bestemt i sera fra 37 hunder med forskjellige leversykdommer. Verdiene for disse parametrene ble sammenliknet med verdiene for aspartat- og alaninaminotransferase (ASAT, ALAT) alkalisk fosfatase (ALP), γ-glutamyl-transferase (γ-GT) og albumin (ALB). GLDH ble funnet å være den mest sensitive enzymparameter (sensitivitet 92 %) og GLDH-verdiene var samtidig et godt mål for graden av levercellenekrose. I sensitivitet fulgte dernest ASAT og ALP. SDH-verdiene var korrelert til ALAT-verdiene, men hadde lav sensitivitet (43 %). 5′-ND skilte vesentlig bedre mellom hepatobiliære og hepatocellulære skader enn ALP, og noe bedre enn γ-GT. GHE hadde et bredt referanseområde (normalomåde), lav sensitivitet og var ikke korrelert til ALB. Enkeltbestemmelser av CHE er derfor trolig uten diagnostisk betydning for hund.
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The authors wish to express their gratitude to the scientific and technical staff of the Department of Pathology for providing the desired histological sections and assisting in the interpretation of these.
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Hange, J.G., Abdelkader, S.V. Serum enzyme determination in the study of liver disease in dogs. Acta Vet Scand 27, 59–70 (1986). https://doi.org/10.1186/BF03548559
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DOI: https://doi.org/10.1186/BF03548559